Product Details
| Cat # +Size | A1057-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | BAR2 |
| Alternate Name | Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor, ADRB2, ADRB2R, B2AR |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | KLH conjugated synthetic peptide between 236-264 amino acids from human BAR2 |
| Accession # | P07550 |
| Gene ID | 154 |
| Appearance | Colourless liquid |
| Concentration | 1 mg/ml |
| Formulation | 100 µg (0.5 mg/ml) of antibody in PBS with 0.09% (W/V) sodium azide. |
| Purification | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS |
| Species Reactivity | Human, Mouse |
| Application | Western blot, IHC |
| Positive Control | Western blot, IHC |
| Application & Usage | WB: 1:1000, IHC: 1:50~101 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
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