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BAG 956

A dual PI3K/PDK-1 inhibitor
Catalog #: 2456
SKU-Size Size Price Qty
2456-5 5 mg
$125.00
2456-25 25 mg
$475.00
More Sizes Get Quote

Product Details

Alternate Name α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyr​idinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-be​nzeneacetonitrile
Appearance Red solid
CAS # 853910-02-8
Molecular Formula C₂₈H₂₁N₅
Molecular Weight 427.5
Purity ≥98% by HPLC
Solubility DMSO (~15 mg/ml) or EtOH (~7 mg/ml)
SMILES CC1=NC2=CN=C3C=CC(=CC3=C2N1C4=CC=C(C=C4)C(C)(C)C#N)C#CC5=CN=CC=C5
InChi InChI=1S/C28H21N5/c1-19-32-26-17-31-25-13-8-20(6-7-21-5-4-14-30-16-21)15-24(25)27(26)33(19)23-11-9-22(10-12-23)28(2,3)18-29/h4-5,8-17H,1-3H3
InChi Key GVPAGJWVBUZHNQ-UHFFFAOYSA-N
PubChem CID 24882589
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, ATP-competitive, dual PI3K/PDK-1 inhibitor in vitro and in vivo (IC₅₀ = 56, 444, 34, 117 and 240 nM for PI3K p110-α ,β,d, γ, and PDK1 kinases, respectively). Displays anticancer properties.


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