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Bafilomycin A1

An inhibitor of vacuolar H⁺-ATPases (V-ATPases)
Catalog #: 1829
SKU-Size Size Price Qty
1829-50 50 µg
$155.00
1829-250 250 µg
$575.00
More Sizes Get Quote

Product Details

Appearance Colorless film
CAS # 88899-55-2
Molecular Formula C₃₅H₅₈O₉
Molecular Weight 622.84
Purity ≥95% by HPLC
Solubility DMSO
SMILES CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C
InChi InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12-,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33?,35+/m0/s1
InChi Key XDHNQDDQEHDUTM-MKFMMVOISA-N
PubChem CID 53321987
MDL Number MFCD06795130
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A highly potent and selective inhibitor of vacuolar H⁺-ATPases (V-ATPases) in vitro. It is effective in nanomolar concentrations in animal cells, plant cells and microorganisms; also selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca²⁺-ATPases, Na⁺/K⁺-ATPases and plasma membrane H⁺-ATPases. Also prevents autophagy at a late stage by inhibiting fusion between autophagosomes and lysosomes.


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