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BAFF Receptor, human recombinant

A TNF receptor that specifically interacts with BAFF
Catalog #: 4452
SKU-Size Size Price Qty
4452-10 10 μg
$80.00
4452-50 50 μg
$190.00
4452-1000 1 mg
$1,950.00
More Sizes Get Quote

Product Details

Alternate Name Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, Short name=BAFF-R, BLyS receptor 3, CD_antigen=CD268
Gene Symbol TR13C
Gene ID 115650
Accession # Q96RJ3
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized from a solution (1 mg/ml) containing 20 mM phosphate buffer, pH 8.0, and 500 mM NaCl.
Molecular Weight 7.7 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg
Biological Activity Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED₅₀ for this effect is typically 1-5 µg/ml in the presence of 1 µg/ml human soluble BAFF.
Reconstitution Instructions Reconstitute in sterile H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers or stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFFR is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFFR/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFFR is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extraCellular portion of the full BAFFR protein.


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