Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

BACE2/Asp1 Antibody

Polyclonal antibody to detect BACE2/Asp1 in human samples.
Catalog #: 6102

In stock

$295.00

Product Details

Cat # +Size 6102-100
Size 100 µg
Antibody Target BACE2
Alternate Name BACE2, Asp1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG1
Immunogen A synthetic peptide corresponding to the amino acids 44 to 59 of human BACE2.
Accession # Q9Y5Z0
Gene ID 25825
Appearance Colorless liquid
Concentration 05 mg/ml
Formulation 100 μg (0.5 mg/ml) affinity purified rabbit anti-BACE2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity chromatography purified via peptide column.
Species Reactivity Human, mouse, rat
Application Western blot
Application & Usage Western Blot: 1-4 μg/ml. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-soμght beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', sμggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.