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BACE Antibody (CT)

Catalog #: 5051

In stock

$325.00

Product Details

Cat # +Size 5051-100
Size 100 µg
Antibody Target BACE
Alternate Name BACE (CT). Asp2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG1
Immunogen A peptide corresponding to 17 amino acids at the CT of human BACE.
Accession # P56817
Gene ID 23621
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.
Purification Ion exchange chromatography.
Species Reactivity Human, mouse
Application Western blot, Immunohistochemistry, ELISA
Positive Control Human brain tissue lysate and mouse 3T3 cell lysate
Application & Usage Immunocytochemistry: 10 μg/ml, Western Blot: 0.5 – 1 μg/ml; ELISA. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-soμght beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.


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