Product Details
| Alternate Name | V-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S1 |
|---|---|
| Gene Symbol | Vtcn1 |
| Gene ID | 242122 |
| Accession # | Q7TSP5 |
| Source | CHO cells |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from 0.2 μm-filtered solution in PBS |
| Purity by SDS-PAGE | ≥98% |
| Endotoxin Level | < 0.06 EU/μg |
| Biological Activity | Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated mouse T cells |
| Reconstitution Instructions | Reconstitute with 100 µl sterile water. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
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