B7-H4 /VTCN1, mouse recombinant

Negatively regulates T-cell-mediated immune response and is involved in promoting epithelial cell transformation
Catalog #: P1107 | abID:

Product Details

Alternate Name V-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S1
Gene Symbol Vtcn1
Gene ID 242122
Accession # Q7TSP5
Source CHO cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.2 μm-filtered solution in PBS
Purity by SDS-PAGE ≥98%
Endotoxin Level < 0.06 EU/μg
Biological Activity Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated mouse T cells
Reconstitution Instructions Reconstitute with 100 µl sterile water.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.

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