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Azurocidin, Human Neutrophil (Cationic protein 37)

An antibiotic protein, with monocyte chemotactic and antibacterial activity
Catalog #: 7287
$265.00

Product Details

Cat # +Size 7287-100
Size 100 μg
Alternate Name Cationic antimicrobial protein CAP37, Heparin-binding protein
Gene Symbol AZU1
Gene ID 566
Accession # P20160
Source Human Neutrophil. Prepared from whole blood shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Appearance Lyophilized
Physical Form Description Salt-free lyophilized solid.
Molecular Weight 37 kDa
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Use deionized water
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

The gene for azurocidin is located on the short arm of chromosome 19 and is in a cluster with the genes for proteinase 3 and elastase. All three proteins are serine protease homologues; azurocidin, however, lacks enzymatic activity. It is an antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, Neutrophil Elastase (NE), and Proteinase 3 (PR3), however, Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced. Azurocidin has been identified as a modulator of endothelial permeability and an important multifunctional inflammatory mediator. Neutrophils arriving first at sites of inflammation release Azurocidin which acts in a paracrine fashion on endothelial cells causing the development of intercellular gaps and allowing leukocyte extravasation. Azurocidin thus be regarded as a reasonable therapeutic target for a variety of inflammatory disease conditions.


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