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A nucleoside reverse transcriptase inhibitor and homology directed repair (HDR) blocker

WARNING: This product can expose you to chemicals including Zidovudine, which is [are] known to the State of California to cause cancer.  For more information go to
Catalog #: B1113
SKU-Size Size Price Qty
B1113-10 10 mg
B1113-50 50 mg
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Product Details

Alternate Name 3'-Azido-3'-deoxythymidine; AZT; Zidovudine
Appearance White solid
CAS # 30516-87-1
Molecular Formula C₁₀H₁₃N₅O₄
Molecular Weight 267.24
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml) or H2O (>10 mg/ml)
InChi InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
PubChem CID 35370
MDL Number MFCD00006536
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Azidothymidine is a nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC₅₀ = 3 nM) with low cytotoxicity (CC₅₀ > 5 μM). Displays 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. Suppresses HIV-1 replication and enhances cell viability in HIV-1 infected T cells. Antiretroviral agent. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency. AZT is a nucleoside analog HIV reverse transcriptase inhibitor that failed to inhibit SARS-CoV-2 replication in vitro.

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