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AZD6244

A potent and selective MEK1/2 inhibitor
Catalog #: 2234
SKU-Size Size Price Qty
2234-5 5 mg
$65.00
2234-25 25 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide; Selumetinib; ARRY-142886
Appearance White to off-white solid
CAS # 606143-52-6
Molecular Formula C₁₇H₁₅BrClFN₄O₃
Molecular Weight 457.68
Purity ≥98% by HPLC
Solubility DMSO
SMILES CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
InChi InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChi Key CYOHGALHFOKKQC-UHFFFAOYSA-N
PubChem CID 10127622
MDL Number MFCD11977472
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent, highly selective and non-ATP competitive inhibitor of mitogen-activated protein kinase kinase 1/2 (MEK1/2) (IC₅₀ = 14 nM/L against purified MEK1). Displays antineoplastic activity.


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