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Product Details
| Alternate Name | 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide; Selumetinib; ARRY-142886 |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 606143-52-6 |
| Molecular Formula | C₁₇H₁₅BrClFN₄O₃ |
| Molecular Weight | 457.68 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO |
| InChi | InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) |
| InChi Key | CYOHGALHFOKKQC-UHFFFAOYSA-N |
| PubChem CID | 10127622 |
| MDL Number | MFCD11977472 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A potent, highly selective and non-ATP competitive inhibitor of mitogen-activated protein kinase kinase 1/2 (MEK1/2) (IC₅₀ = 14 nM/L against purified MEK1). Displays antineoplastic activity.
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