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Product Details
| Alternate Name | (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 935666-88-9 |
| Molecular Formula | C₁₄H₁₄ClFN₈ |
| Molecular Weight | 348.77 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~70 mg/ml) or Ethanol (~ 5 mg/ml) |
| SMILES | CC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F |
| InChi | InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 |
| InChi Key | PDOQBOJDRPLBQU-QMMMGPOBSA-N |
| PubChem CID | 16659841 |
| MDL Number | MFCD16038904 |
| Handling | Protect from air and light |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ of 1.3 nM and 0.26 nM, respectively.
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