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AZD-9291

A mutant-selective EGFR tyrosine kinase inhibitor
Catalog #: 2674
SKU-Size Size Price Qty
2674-5 5 mg
$95.00
2674-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name N-​[2-​[[2-​(Dimethylamino)​ethyl]​methylamino]​-​4-​methoxy-​5-​[[4-​(1-​methyl-​1H-​indol-​3-​yl)​-​2-​pyrimidinyl]​amino]​phenyl]​- 2-​propenamide
Appearance Crystalline solid
CAS # 1421373-65-0
Molecular Formula C₂₈H₃₃N₇O₂
Molecular Weight 499.61
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
InChi InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)
InChi Key DUYJMQONPNNFPI-UHFFFAOYSA-N
PubChem CID 71496458
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AZD-9291 is a potent, third generation, mutant-selective EGFR tyrosine kinase inhibitor. It is effective against both EGFR-TKI sensitizing and resistance T790M mutations. Displays anticancer properties.


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