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Product Details
| Alternate Name | AZD-5363; AZD 5363; AZD5363; Capivasertib; (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide; 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide |
|---|---|
| Appearance | Solid |
| CAS # | 1143532-39-1 |
| Molecular Formula | C₂₁H₂₅ClN₆O₂ |
| Molecular Weight | 428.92 |
| Purity | >98% |
| Solubility | DMSO |
| SMILES | C1CN(CCC1(C(=O)NC(CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 |
| InChi | InChI=1S/C21H25ClN6O2/c22-15-3-1-14(2-4-15)17(6-12-29)27-20(30)21(23)7-10-28(11-8-21)19-16-5-9-24-18(16)25-13-26-19/h1-5,9,13,17,29H,6-8,10-12,23H2,(H,27,30)(H,24,25,26)/t17-/m0/s1 |
| InChi Key | JDUBGYFRJFOXQC-KRWDZBQOSA-N |
| PubChem CID | 25227436 |
| MDL Number | MFCD22628785 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
AZD5363, also known as Capivasertib, is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
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