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AZD-5069

A potent and reversible CXCR2 chemokine receptor antagonist
Catalog #: B2053
SKU-Size Size Price Qty
B2053-5 5 mg
$145.00
B2053-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
Appearance White to off-white solid
CAS # 878385-84-3
Molecular Formula C₁₈H₂₂F₂N₄O₅S₂
Molecular Weight 476.51
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C(CO)O)OC1=NC(=NC(=C1)NS(=O)(=O)N2CCC2)SCC3=C(C(=CC=C3)F)F
InChi InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22-16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2,1H3,(H,21,22,23)/t11-,14+/m1/s1
InChi Key QZECRCLSIGFCIO-RISCZKNCSA-N
PubChem CID 56645576
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AZD-5069 is a potent and reversible CXCR2 chemokine receptor antagonist with potential anti-inflammatory and antineoplastic activities. Upon administration, CXC chemokine receptor 2 antagonist AZD5069 directly binds to CXCR2 and inhibits its activation. This inhibits CXCR2-mediated signaling and may inhibit tumor cell proliferation in CXCR2-overexpressing tumor cells.


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