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AZD-3965

A potent and selective monocarboxylate transporter 1 (MCT1) inhibitor
Catalog #: B2227

In stock

SKU-Size Size Price Qty
B2227-1 1 mg
$85.00
B2227-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name (S)-5-(4-hydroxy-4-methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Appearance White solid
CAS # 1448671-31-5
Molecular Formula C₂₁H₂₄F₃N₅O₅S
Molecular Weight 515.51
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1=C(C(=NN1)C(F)(F)F)CC2=C(C3=C(S2)N(C(=O)N(C3=O)C)C(C)C)C(=O)N4CC(CO4)(C)O
InChi InChI=1S/C21H24F3N5O5S/c1-9(2)29-18-14(16(30)27(5)19(29)32)13(17(31)28-7-20(4,33)8-34-28)12(35-18)6-11-10(3)25-26-15(11)21(22,23)24/h9,33H,6-8H2,1-5H3,(H,25,26)/t20-/m0/s1
InChi Key PRNXOFBDXNTIFG-FQEVSTJZSA-N
PubChem CID 10369242
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AZD-3965 is a potent and selective monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM; it is 6-fold selective over MCT2 and does not inhibit MCT4 even at 10 μM. AZD 3965 increases intratumor lactate levels and decreases tumor growth in mice bearing COR-L103 small cell lung cancer (SCLC) xenografts.


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