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AZD-3229

A potent pan-KIT mutant inhibitor
Catalog #: B2513
SKU-Size Size Price Qty
B2513-1 1 mg
$115.00
B2513-5 5 mg
$425.00
More Sizes Get Quote

Product Details

Alternate Name AZD3229; N-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide
Appearance Crystalline solid
CAS # 2248003-60-1
Molecular Formula C₂₄H₂₆FN₇O₃
Molecular Weight 479.52
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
SMILES CC(C)C1=CN(N=N1)CC(=O)NC2=CC=C(C=C2)NC3=NC=NC4=CC(=CC(=C43)F)OCCOC
InChi InChI=1S/C24H26FN7O3/c1-15(2)21-12-32(31-30-21)13-22(33)28-16-4-6-17(7-5-16)29-24-23-19(25)10-18(35-9-8-34-3)11-20(23)26-14-27-24/h4-7,10-12,14-15H,8-9, 13H2,1-3H3,(H,28,33)(H,26,27,29)
InChi Key FLJOFQUXYAWOPE-UHFFFAOYSA-N
PubChem CID 134814269
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AZD3229 is a potent, pan-KIT mutant inhibitor that displays single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V). Potentially could be useful for the treatment of gastrointestinal stromal tumors.


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