A highly selective JAK1 inhibitor
Catalog #: B3124 | abID:

Product Details

Alternate Name JAK1-IN-3; (2R)-N-[3-[2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide; 1-Piperazineacetamide, N-(3-(2-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-4-pyrimidinyl)-1H-indol-7-yl)-alpha,4-dimethyl-, (alphaR)-
Appearance Off-white crystalline powder
CAS # 2091134-68-6
Molecular Formula C₂₅H₃₁N₉O₂
Molecular Weight 489.6
Purity ≥ 98%
Solubility ~50 mg/ml in DMSO
InChi InChI=1S/C25H31N9O2/c1-16(34-12-10-32(2)11-13-34)23(35)28-20-7-5-6-17-18(14-27-22(17)20)19-8-9-26-25(29-19)30-21-15-33(3)31-24(21)36-4/h5-9,14-16,27H,10-13H2,1-4H3,(H,28,35)(H,26,29,30)/t16-/m1/s1
PubChem CID 126715380
MDL Number MFCD31657353
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AZD-4205 is a highly selective Janus Kinase 1 (JAK1) inhibitor with an IC₅₀ of 0.07 μM. It shows antitumor activity in combination with the EGFR inhibitor, osimertinib, in a preclinical non-small-cell lung cancer xenograft NCI-H1975 model. It targets cancer stem cell associated signalling pathway and microenvironment and is being evaluated in phase II clinical trials to treat advanced non-small-cell lung cancer.

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