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AZD-2461

An inhibitor of PARP
Catalog #: B3103
SKU-Size Size Price Qty
B3103-5 5 mg
$80.00
B3103-25 25 mg
$320.00
More Sizes Get Quote

Product Details

Alternate Name 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one; 4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one
Appearance White to beige powder
CAS # 1174043-16-3
Molecular Formula C₂₂H₂₂FN₃O₃
Molecular Weight 395.43
Purity ≥ 98%
Solubility ~20 mg/ml in DMSO
SMILES COC1CCN(CC1)C(=O)C2=C(C=CC(=C2)CC3=NNC(=O)C4=CC=CC=C43)F
InChi InChI=1S/C22H22FN3O3/c1-29-15-8-10-26(11-9-15)22(28)18-12-14(6-7-19(18)23)13-20-16-4-2-3-5-17(16)21(27)25-24-20/h2-7,12,15H,8-11,13H2,1H3,(H,25,27)
InChi Key HYNBNUYQTQIHJK-UHFFFAOYSA-N
PubChem CID 44199317
MDL Number MFCD24386811
Handling FOR RESEARCH USE ONLY! Not to be used on humans.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AZD-2461 is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP1 and PARP2 with IC₅₀ values of 5 nM and 2 nM. It has lower affinity for P-glycoprotein and suppresses the development of drug resistance.


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