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AZD-6482

A potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ)
Catalog #: B1143
SKU-Size Size Price Qty
B1143-5 5 mg
$145.00
B1143-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name (-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
Appearance Off White solid
CAS # 1173900-33-8
Molecular Formula C₂₂H₂₄N₄O₄
Molecular Weight 408.45
Purity ≥98% by HPLC
Solubility DMSO (>35 mg/ml)
SMILES CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3C(=O)O)N4CCOCC4
InChi InChI=1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m1/s1
InChi Key IRTDIKMSKMREGO-OAHLLOKOSA-N
PubChem CID 44137675
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AZD-6482 is a potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC₅₀ values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively).  It displays 80-fold selectivity for PI3Kβ over PI3k-C2 and DNA-PK and more than 1,000-fold over other PI3K-related kinases. AZD6482 blocks Akt signaling and tumor growth in a large number of cancer cell lines, including those that are dependent on PI3Kβ activation or PTEN loss.


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