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AZD6738 is an orally active and bioavailable ATR kinase inhibitor
Catalog #: B1167
SKU-Size Size Price Qty
B1167-5 5 mg
B1167-25 25 mg
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Product Details

Alternate Name 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine
Appearance White Solid
CAS # 1352226-88-0
Molecular Formula C₂₀H₂₄N₆O₂S
Molecular Weight 412.51
Purity ≥98% by HPLC
Solubility DMSO (~0.5 mg/ml)
InChi InChI=1S/C20H24N6O2S/c1-12-11-28-8-7-26(12)18-10-16(15-9-17(15)29(2,21)27)24-20(25-18)14-4-6-23-19-13(14)3-5-22-19/h3-6,10,12,15,17,21H,7-9,11H2,1-2H3,(H,22,23)/t12-,15?,17-,29-/m1/s1
PubChem CID 121228639
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AZD6738 is a potent ATR kinase inhibitor with IC₅₀ value of 1 nM against the isolated enzyme. AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.  It also induces cell death and senescence in non-small cell lung cancer (NSCLC) cell lines.

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