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AZD-8931

A potent, ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3
Catalog #: 9659
SKU-Size Size Price Qty
9659-5 5 mg
$145.00
9659-25 25 mg
$525.00
More Sizes Get Quote

Product Details

Alternate Name 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline; Sapitinib; Momelotinib.
Appearance Crystalline solid
CAS # 848942-61-0
Molecular Formula C₂₃H₂₅ClFN₅O₃
Molecular Weight 473.93
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC
InChi InChI=1S/C23H25ClFN5O3/c1-26-21(31)12-30-8-6-14(7-9-30)33-20-10-15-18(11-19(20)32-2)27-13-28-23(15)29-17-5-3-4-16(24)22(17)25/h3-5,10-11,13-14H,6-9,12H2,1-2H3,(H,26,31)(H,27,28,29)
InChi Key DFJSJLGUIXFDJP-UHFFFAOYSA-N
PubChem CID 11488320
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AZD-8931 is a potent, ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3 (the IC₅₀ values are 4 nM, 3 nM and 4 nM, respectively).


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