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AZ-960

A potent and specific JAK2 kinase inhibitor
Catalog #: B2065
SKU-Size Size Price Qty
B2065-5 5 mg
$145.00
B2065-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name (S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Appearance Crystalline solid
CAS # 905586-69-8
Molecular Formula C₁₈H₁₆F₂N₆
Molecular Weight 354.36
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1=CC(=NN1)NC2=C(C=C(C(=N2)NC(C)C3=CC=C(C=C3)F)C#N)F
InChi InChI=1S/C18H16F2N6/c1-10-7-16(26-25-10)23-18-15(20)8-13(9-21)17(24-18)22-11(2)12-3-5-14(19)6-4-12/h3-8,11H,1-2H3,(H3,22,23,24,25,26)/t11-/m0/s1
InChi Key SUNXHXDJOIXABJ-NSHDSACASA-N
PubChem CID 25099184
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AZ-960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM. AZ-960 induces growth arrest and apoptosis of human T-cell lymphotropic virus type 1, HTLV-1-infected T cells (MT-1 and MT-2) in parallel with downregulation of the phosphorylated forms of Jak2 and Bcl-2 family proteins including Bcl-2 and Mcl-1.


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