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AZ-191

A potent and selective DYRK1B inhibitor
Catalog #: B3288
SKU-Size Size Price Qty
B3288-5 5 mg
$115.00
B3288-25 25 mg
$425.00
More Sizes Get Quote

Product Details

Alternate Name N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine AZ191
Peptide Sequence N/A
Appearance Off-white solid
CAS # 1594092-37-1
Molecular Formula C₂₄H₂₇N₇O
Molecular Weight 429.52
Purity ≥98% by HPLC
Solubility >35 mg/ml DMSO
SMILES CN2C=C(C3=CC=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=N3)C1=CC=NC=C12
InChi InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)
InChi Key ZYVXTMKTGDARKR-UHFFFAOYSA-N
PubChem CID 72716071
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AZ-191 is a potent and selective DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) inhibitor (IC50 = 17 nM). AZ-191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B is amplified in certain cancers and may be an oncogene.


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