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A potent dual BRAF inhibitor
Catalog #: B2571
SKU-Size Size Price Qty
B2571-5 5 mg
B2571-25 25 mg
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Product Details

Alternate Name 3-(2-cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide, AZ304, AZ 304
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 942507-42-8
Molecular Formula C₂₇H₂₅N₅O₂
Molecular Weight 451.53
Purity ≥98%
Solubility in DMSO
InChi InChI=1S/C27H25N5O2/c1-17-8-9-20(31-26(33)18-6-5-7-19(12-18)27(2,3)15-28)13-23(17)32-25-22-11-10-21(34-4)14-24(22)29-16-30-25/h5-14,16H,1-4H3,(H,31,33)(H,29,30,32)
PubChem CID 16202218
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AZ-304 is a potent, ATP-competitive dual BRAF kinase inhibitor that inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC₅₀s of 79 nM, 38 nM and 68 nM, respectively. In addition, AZ-304 exhibits significant effect on other kinases such as p38 (IC₅₀, 6 nM), CSF1R (IC₅₀, 35 nM). AZ-304 exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status.

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