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AZ-3146

potent and selective Mps1 (monopolar spindle 1) kinase inhibitor
Catalog #: B1145
SKU-Size Size Price Qty
B1145-5 5 mg
$125.00
B1145-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Appearance White Solid
CAS # 1124329-14-1
Molecular Formula C₂₄H₃₂N₆O₃
Molecular Weight 452.55
Purity ≥98% by HPLC
Solubility DMSO(>10 mg/ml))
SMILES CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
InChi 1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
InChi Key YUKWVHPTFRQHMF-UHFFFAOYSA-N
PubChem CID 56973724
MDL Number MFCD18384959
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AZ 3146 is a potent and selective Mps1 (monopolar spindle 1) kinase inhibitor (IC₅₀ = 35 nM). Shows selectivity over 46 other kinases including aurora kinase B and Cdk1. AZ 3146 overrides spindle assembly checkpoint and also interferes with chromosome alignment. It has shown to inhibit the recruitment of Mad1, 2 and centromere protein E (CENP-E) to kinetochores.


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