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AX-024 hydrochloride

A T cell receptor (TCR) inhibitor
Catalog #: B2013

In stock

SKU-Size Size Price Qty
B2013-5 5 mg
$145.00
B2013-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride; AX024
Appearance Crystalline solid
CAS # 1704801-24-0
Molecular Formula C₂₁H₂₂FNO₂.HCl
Molecular Weight 375.86
Purity ≥98% by HPLC
Solubility DMSO
SMILES COC1=CC2=C(C=C1)OCC(=C2C3=CC=C(C=C3)F)CN4CCCC4.Cl
InChi InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H
InChi Key DGBCIMPGYRVTPD-UHFFFAOYSA-N
PubChem CID 129909862
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AX-024 is a T cell receptor (TCR) inhibitor. An orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC₅₀ = 1 nM). By modulating TCR signaling, the inhibitor prevents the development of psoriasis and asthma. Additionally, it exerts a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis.


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