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AVL-292 (Spebrutinib)

A potent, selective inhibitor of Bruton’s Tyrosine Kinase (BTK)
Catalog #: 9413
SKU-Size Size Price Qty
9413-5 5 mg
9413-25 25 mg
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Product Details

Alternate Name N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide; CC-292
Appearance White to off-white solid
CAS # 1202757-89-8
Molecular Formula C₂₂H₂₂FN₅O₃
Molecular Weight 423.44
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
InChi InChI=1S/C22H22FN5O3/c1-3-20(29)25-16-5-4-6-17(13-16)26-21-19(23)14-24-22(28-21)27-15-7-9-18(10-8-15)31-12-11-30-2/h3-10,13-14H,1,11-12H2,2H3,(H,25,29)(H2,24,26,27,28)
PubChem CID 59174488
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AVL-292 is a potent, selective inhibitor of Bruton’s Tyrosine Kinase (BTK) (IC₅₀ = 0. 5 nM) with potential antineoplastic activity.

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