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An acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor
Catalog #: 9506
SKU-Size Size Price Qty
9506-5 5 mg
9506-25 25 mg
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Product Details

Alternate Name [2,6-di(propan-2-yl)phenyl] N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate; CI-1011; PD 148515
Appearance White to off-white solid
CAS # 166518-60-1
Molecular Formula C₂₉H₄₃NO₄S
Molecular Weight 501.72
Purity ≥98% by HPLC
Solubility DMSO (>35 mg/ml)
InChi InChI=1S/C29H43NO4S/c1-17(2)22-14-25(20(7)8)27(26(15-22)21(9)10)16-28(31)30-35(32,33)34-29-23(18(3)4)12-11-13-24(29)19(5)6/h11-15,17-21H,16H2,1-10H3,(H,30,31)
PubChem CID 166558
MDL Number MFCD00934956
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Avasimibe is an orally bioavailable inhibitor of the acyl coenzyme A: cholesterol acyltransferase (ACAT) (IC₅₀ = 60 nM). Avasimibe also inhibits major drug metabolizing enzymes such as CYP2C9 (IC₅₀ = 2.9 µM ), CYP1A2 (IC₅₀ = 13.9 µM), and CYP2C19 (IC₅₀ = 26.5 µM).

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