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Product Details
| Alternate Name | 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine |
|---|---|
| Appearance | White solid |
| CAS # | 1644443-47-9 |
| Molecular Formula | C₁₄H₁₁ClN₆O₃ |
| Molecular Weight | 346.73 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>6 mg/ml) |
| SMILES | CC1=CC(=NN1)NC2=CC(=NC(=N2)OC3=CC=C(C=C3)[N+](=O)[O-])Cl |
| InChi | InChI=1S/C14H11ClN6O3/c1-8-6-13(20-19-8)17-12-7-11(15)16-14(18-12)24-10-4-2-9(3-5-10)21(22)23/h2-7H,1H3,(H2,16,17,18,19,20) |
| InChi Key | CEUMAXLRGBKFQP-UHFFFAOYSA-N |
| PubChem CID | 129626605 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Autophinib is a potent autophagy inhibitor. It inhibits autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.
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