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A potent autophagy inhibitor
Catalog #: B2260
SKU-Size Size Price Qty
B2260-5 5 mg
B2260-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
Appearance White solid
CAS # 1644443-47-9
Molecular Formula C₁₄H₁₁ClN₆O₃
Molecular Weight 346.73
Purity ≥98% by HPLC
Solubility DMSO (>6 mg/ml)
SMILES CC1=CC(=NN1)NC2=CC(=NC(=N2)OC3=CC=C(C=C3)[N+](=O)[O-])Cl
InChi InChI=1S/C14H11ClN6O3/c1-8-6-13(20-19-8)17-12-7-11(15)16-14(18-12)24-10-4-2-9(3-5-10)21(22)23/h2-7H,1H3,(H2,16,17,18,19,20)
PubChem CID 129626605
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Autophinib is a potent autophagy inhibitor. It inhibits autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.

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