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Aurora Kinase B Inhibitor (AZD1152-HQPA)

An Aurora kinase B inhibitor
Catalog #: 1583
SKU-Size Size Price Qty
1583-5 5 mg
$205.00
1583-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name AZD1152-HQPA
Appearance Crystalline solid
CAS # 722544-51-6
Molecular Formula C₂₆H₃₀FN₇O₃
Molecular Weight 507.56
Purity ≥99% by HPLC
Solubility DMSO
SMILES CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
InChi InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
InChi Key QYZOGCMHVIGURT-UHFFFAOYSA-N
PubChem CID 16007391
MDL Number MFCD10687152
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and specific Aurora kinase B inhibitor. It is 1000-fold more selective for aurora kinase B than for aurora kinase A ( Ki values of 1300 nM and 0.36 nM for aurora kinase A and B, respectively). At concentrations as low as 0.01 µM, AZD 1152 produced a significant (p<0.05) decrease in the ability of NB4 cells to proliferate by 48 hours.


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