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A potent PTEFb/CDK9 Inhibitor
Catalog #: B2440
SKU-Size Size Price Qty
B2440-1 1 mg
B2440-5 5 mg
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Product Details

Alternate Name (3-((4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl)amino)benzyl)(imino)(methyl)-l6-sulfanone, BAY -1143572, BAY 1143572
Appearance Crystalline solid
CAS # 1414943-88-6
Molecular Formula C₁₈H₁₈FN₅O₂S
Molecular Weight 387.433
Purity ≥98% by HPLC
Solubility in DMSO
InChi InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20) 25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24)
PubChem CID 71618220
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Atuveciclib (BAY-1143572) is a potent and selective CDK9/P-TEFb inhibitor (IC₅₀ = 6 nM for CDK9/CyclinT1); displays >150-fold selectivity over CDK1/2/3/5/6/7 (IC₅₀ >800 nM). Exhibits anticancer activity in human AML models.

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