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ATR Antibody

Catalog #: 3767
$265.00

Product Details

Cat # +Size 3767-100
Size 100 µl
Antibody Target ATR
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide of human ATR
Accession # Q13535
Gene ID 545
Appearance Colorless liquid
Formulation 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse
Application Western blot
Application & Usage Western blotting (1:1000 – 1:2000). HeLa cell lysate can be used as a positive control. However, the optimal concentrations should be determined individually. The antibody recognizes the ATR of human and mouse origins. Reactivity to other species has not
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.


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