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Atovaquone

A broad-spectrum antiprotozoal agent
Catalog #: B2640
SKU-Size Size Price Qty
B2640-10 10 mg
$75.00
B2640-50 50 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name BW 556C-80; Mepron; BW 566C; trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
Appearance Orange solid
CAS # 95233-18-4
Molecular Formula C₂₂H₁₉ClO₃
Molecular Weight 366.84
Purity ≥98% by HPLC
Solubility >7 mg/ml DMSO
SMILES C1CC(CCC1C2=CC=C(C=C2)Cl)C3=C(C4=CC=CC=C4C(=O)C3=O)O
InChi InChI=1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,24H,5-8H2
InChi Key BSJMWHQBCZFXBR-UHFFFAOYSA-N
PubChem CID 74989
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Atovaquone is a broad-spectrum antiprotozoal agent that is active against Plasmodium, Toxoplasma, and Babesia, among other protozoa. It inhibits complex III activity on dihydroorotate in isolated P. falciparum and P. yoelii mitochondria more potently than in rat liver mitochondria (EC50s = 0.95, 0.94, and 510 nM, respectively) and depolarizes the mitochondrial membrane in P. yoelii-infected mouse erythrocytes (EC50 = 260 nM). Atovaquone also inhibits transport mediated by human breast cancer resistance protein (BCRP) and P-glycoprotein in membrane vesicles (IC50s = 0.23 and 6.8 μM, respectively.


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