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Atorvastatin

A potent HMG-CoA reductase inhibitor
Catalog #: 2278
SKU-Size Size Price Qty
2278-10 10 mg
$75.00
2278-50 50 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 2-​(4-​fluorophenyl)-​βR,​δR-​dihydroxy-​5-​(1-​methylethyl)-​3-​phenyl- ​4-​[(phenylamino)carbonyl]-​1H-​pyrrole-​1-​heptanoic acid
Appearance White solid
CAS # 134523-00-5
Molecular Formula C₃₃H₃₅FN₂O₅
Molecular Weight 558.64
Purity ≥98%
Solubility DMSO (~15 mg/ml) or EtOH (~0.5 mg/ml)
SMILES CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
InChi InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1
InChi Key XUKUURHRXDUEBC-KAYWLYCHSA-N
PubChem CID 60823
MDL Number MFCD00899261
Handling Protect from air and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cholesterol lowering drug and a competitive inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase (IC₅₀ = 154 nM) a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. In addition to inhibiting cholesterol synthesis, atorvastatin reduces the production of low-density lipoprotein (LDL).


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