Product Details
| Cat # +Size | 1685-5 |
|---|---|
| Size | 5 mg |
| Alternate Name | 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933 |
| Appearance | White solid |
| CAS # | 587871-26-9 |
| Molecular Formula | C₂₁H₁₇NO₃S₂ |
| Molecular Weight | 395.49 |
| Purity | ≥97% by HPLC |
| Solubility | DMSO (100 mM) and Ethanol (50 mM) |
| SMILES | C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4 |
| InChi | InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2 |
| InChi Key | XRKYMMUGXMWDAO-UHFFFAOYSA-N |
| PubChem CID | 5278396 |
| MDL Number | MFCD08276985 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600, >100000 and >100000 nM, respectively).
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Ortega-Atienza et al., ATM and KAT5 safeguard replicating chromatin against formaldehyde damage. Nucleic Acids Res., Sep 2015; 10.1093/nar/gkv957.
DeLoughery et al., DNA Double-Strand Breaks by Cr(VI) Are Targeted to Euchromatin and Cause ATR-Dependent Phosphorylation of Histone H2AX and Its Ubiquitination. Toxicol. Sci., Jan 2015; 143: 54 - 63.
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