ATM Kinase Inhibitor, KU-55933

An ATM kinase inhibitor
Catalog #: 1685 | abID:

Product Details

Cat # +Size 1685-5
Size 5 mg
Alternate Name 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933
Appearance White solid
CAS # 587871-26-9
Molecular Formula C₂₁H₁₇NO₃S₂
Molecular Weight 395.49
Purity ≥97% by HPLC
Solubility DMSO (100 mM) and Ethanol (50 mM)
InChi InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
PubChem CID 5278396
MDL Number MFCD08276985
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600, >100000 and >100000 nM, respectively).

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Ortega-Atienza et al., ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.  Nucleic Acids Res., Sep 2015; 10.1093/nar/gkv957.
DeLoughery et al., DNA Double-Strand Breaks by Cr(VI) Are Targeted to Euchromatin and Cause ATR-Dependent Phosphorylation of Histone H2AX and Its Ubiquitination. Toxicol. Sci., Jan 2015; 143: 54 - 63.
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