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ATM Antibody

Catalog #: 3813
$265.00

Product Details

Cat # +Size 3813-100
Size 100 μl
Antibody Target ATM
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide from human Ataxia Telangiectasia Mutated (ATM)
Accession # Q13315
Gene ID 472
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal
Purification Affinity purified
Species Reactivity Human, mouse
Application Western blot, Immunoprecipitation
Application & Usage Western blotting (1:500-2000) and immunoprecipitation. However, the optimal concentrations should be determined individually. Human L-40 cell lysate can be used as a positive control for Western blotting. The antibody recognizes ATM in samples from human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy termini that is not present in the PI 3- and PI 4-kinases. All of the members of the PIK-related kinases are also larger than 270 kDa. The ATM gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT), which is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiectases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and they display delays in p53 induction.


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