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Product Details
| Cat # +Size | 5070-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | ATG16 |
| Alternate Name | Autophagy protein 16, Autophagy related protein 16, ATG16L, APG16 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG1 |
| Immunogen | ATG16 antibody was raised against a 18 amino acid peptide from near the center of human ATG16. |
| Accession # | Q676U5 |
| Gene ID | 55054 |
| Appearance | Colorless liquid |
| Concentration | 1 mg/ml |
| Formulation | 100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide. |
| Purification | Affinity chromatography purified via peptide column. |
| Species Reactivity | Human, mouse, rat |
| Application | Western blot, Immunocytochemistry, ELISA |
| Positive Control | Western Blot: HeLa cell lysateImmunocytochemistry: HeLa cells |
| Application & Usage | Western Blot: 0.25 – 0.5 μg/ml, Immunocytochemistry: 2 μg/ml, ELISA. However, the optimal conditions should be determined individually. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) throμgh phosphorylation of autophagy protein APG1. ATG16, another member of the autophagy protein family, forms a complex with the ATG5-ATG12 conjμgate. This multimeric protein has been shown to be essential for autophagosome formation in both yeast and mammals and targets the ATG5-ATG12 complex to the autophagic isolation membrane during the formation of the autophagosome. Because mammalian ATG16 has seven WD-repeats in its C-terminal domain, it has been sμggested that these may form a platform for further protein-protein interactions. Multiple isoforms of ATG16 are known to exist.
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