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AT9283

A multi-targeted c-Abl, JAK2, Aurora A and B inhibitor
Catalog #: 2432
SKU-Size Size Price Qty
2432-5 5 mg
$135.00
2432-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
Appearance Off-white solid
CAS # 896466-04-9
Molecular Formula C₁₉H₂₃N₇O₂
Molecular Weight 381.43
Purity ≥98% by HPLC
Solubility DMSO (>70 mg/ml) or EtOH (>25 mg/ml)
SMILES C1CC1NC(=O)NC2=CNNC2=C3N=C4C=CC(=CC4=N3)CN5CCOCC5
InChi InChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13,20,25H,2-3,5-8,11H2,(H2,21,24,27)/b18-17-
InChi Key VRXXZJLHPWWXIX-ZCXUNETKSA-N
PubChem CID 11696609
Handling Protect from light and air
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A pan-Aurora kinase inhibitor (IC₅₀ = 3 nM for both Aurora A and B). AT9283 also potently inhibits several kinases including the JAK2 and 3 (IC₅₀’s 1.2 and 1.1 nM, respectively), c-Abl(IC₅₀ = 110 nM) and Abl/T315I (IC₅₀ = 4 nM).


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