Product Details
| Alternate Name | 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine |
|---|---|
| Appearance | White solid |
| CAS # | 857531-00-1 |
| Molecular Formula | C₂₀H₂₀ClN₃ |
| Molecular Weight | 337.9 |
| Purity | ≥97% by HPLC |
| Solubility | DMSO (~0.33 mg/ml) |
| SMILES | C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl |
| InChi | InChI=1S/C20H20ClN3/c21-19-7-5-18(6-8-19)20(9-11-22-12-10-20)17-3-1-15(2-4-17)16-13-23-24-14-16/h1-8,13-14,22H,9-12H2,(H,23,24) |
| InChi Key | LZMOSYUFVYJEPY-UHFFFAOYSA-N |
| PubChem CID | 11175137 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
AT7867 is a potent inhibitor of Akt isoforms Akt1, 2, and 3 (IC₅₀s = 32, 17, and 47 nM, respectively). It also inhibits p70S6 kinase and PKA (IC₅₀s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases. AT7867 inhibits growth and induces apoptosis in a variety of cancer cell lines in vitro and suppresses tumor growth of PTEN-deficient xenografts in mice.
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