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AT-7519 hydrochloride

A potent CDK inhibitor
Catalog #: 2816
SKU-Size Size Price Qty
2816-5 5 mg
$95.00
2816-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride
Appearance White solid
CAS # 902135-91-5
Molecular Formula C₁₆H₁₈Cl₃N₅O₂
Molecular Weight 418.71
Purity ≥98% by HPLC
Solubility DMSO
SMILES C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.Cl
InChi InChI=1S/C16H17Cl2N5O2.ClH/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);1H
InChi Key PAOFPNGYBWGKCO-UHFFFAOYSA-N
PubChem CID 25033099
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AT-7519 is a potent CDK inhibitor with potential antineoplastic activity. AT-7519 displays potent antiproliferative activity (40-940 nM) in a panel of human tumor cell lines, and the mechanism of action is shown to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT-7519 causes cell cycle arrest followed by apoptosis in human tumor cells and inhibits tumor growth in human tumor xenograft models.


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