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AT 56

A selective, competitive, and highly bioavailable inhibitor of L-PGDS (lipocalin-type prostaglandin D synthase)
Catalog #: 2592
SKU-Size Size Price Qty
2592-5 5 mg
2592-25 25 mg
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Product Details

Alternate Name 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine
Appearance White solid
CAS # 162640-98-4
Molecular Formula C₂₅H₂₇N₅
Molecular Weight 397.52
Purity ≥98% by HPLC
Solubility DMSO (>15 mg/ml)
InChi InChI=1S/C25H27N5/c1-3-9-22-19(7-1)12-13-20-8-2-4-10-23(20)25(22)21-14-17-30(18-15-21)16-6-5-11-24-26-28-29-27-24/h1-4,7-10,12-13H,5-6,11,14-18H2,(H,26,27,28,29)
PubChem CID 11741525
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AT-56 is a selective, competitive, and highly bioavailable inhibitor of L-PGDS (lipocalin-type prostaglandin D synthase) (Ki = 75 µM). It inhibits the production of PGD2 by L-PGDS purified from human CSF and recombinant mouse cells with an IC₅₀ value of 95 µM. At concentrations as high as 100 µM in vitro or 30 mg/kg in vivo, AT-56 does not affect the production of PGE2, PGF2α, or H-PGDS-catalyzed PGD2.

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