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AT13148 is a potent multi-AGC kinase inhibitor
Catalog #: B1144
SKU-Size Size Price Qty
B1144-5 5 mg
B1144-25 25 mg
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Product Details

Alternate Name (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol
Appearance White Solid
CAS # 1056901-62-2
Molecular Formula C₁₇H₁₆ClN₃O
Molecular Weight 313.78
Purity ≥98% by HPLC
Solubility DMSO(>5 mg/ml))
InChi 1S/C17H16ClN3O/c18-16-7-5-15(6-8-16)17(22,11-19)14-3-1-12(2-4-14)13-9-20-21-10-13/h1-10,22H,11,19H2,(H,20,21)/t17-/m0/s1
PubChem CID 24905401
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


AT13148 is a potent, ATP-competitive multi-AGC kinase inhibitor that displays antitumor activity. AT13148 blocks AKT, p70S6K, PKA, ROCK, and SGK substrate phosphorylation inducing concentration dependent apoptosis in cancer cells. It also shows anti-tumor efficacy in HER2-positive, PIK3CA-mutant BT474 breast, PTEN-deficient PC3 human prostate cancer and PTEN deficient MES-SA uterine tumor in xenografts. Gene expression studies shows that AT13148 has a predominant effect on apoptosis genes.

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