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AT-13387

A potent heat shock protein 90 (Hsp90) inhibitor
Catalog #: B1961

In stock

SKU-Size Size Price Qty
B1961-5 5 mg
$125.00
B1961-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name (2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone; Onalespib
Appearance Crystalline solid
CAS # 912999-49-6
Molecular Formula C₂₄H₃₁N₃O₃
Molecular Weight 409.5
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES CC(C)C1=C(C=C(C(=C1)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C)O)O
InChi InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3
InChi Key IFRGXKKQHBVPCQ-UHFFFAOYSA-N
PubChem CID 11955716
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AT-13387 is a synthetic, orally bioavailable and small-molecule inhibitor of heat shock protein 90 (Hsp90) with IC₅₀ value of 18 nM in A375 cells. Hsp90 acts as a “molecular chaperone” stabilizing and preventing the breakdown of key cancer-forming (oncogenic) proteins.


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