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AT-101

A Bcl-2 inhibitor and apoptosis inducer
Catalog #: 2380
SKU-Size Size Price Qty
2380-5 5 mg
$105.00
2380-25 25 mg
$420.00
More Sizes Get Quote

Product Details

Alternate Name (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dim­ethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8­,8'-dicarboxaldehyde; (R)-Gossypol
Appearance Light brown solid
CAS # 90141-22-3
Molecular Formula C₃₀H₃₀O₈
Molecular Weight 518.56
Purity ≥98% by TLC
Solubility DMSO (~50 mg/ml) or EtOH (~50 mg/ml)
SMILES OC1=C(O)C(C(C)C)=C(C=C(C)C(C2=C(O)C(C(C([H])=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)=C4O)C4=C1C([H])=O
InChi InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
InChi Key QBKSWRVVCFFDOT-UHFFFAOYSA-N
PubChem CID 227456
Handling Protect from light and air
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

AT-101 is the R-(-) enantiomer of Gossypol that acts as an inhibitor of the antiapoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and an inducer of the pro-apoptotic proteins noxa and puma. It induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway.


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