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Astragalin

A flavonoid with anti-inflammatory and anti-oxidant activity
Catalog #: B2964
SKU-Size Size Price Qty
B2964-1 1 mg
$65.00
B2964-5 5 mg
$260.00
More Sizes Get Quote

Product Details

Alternate Name 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one; kaempferol-3-glucoside; 3-(β-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Kaempferol 3-β-D-glucopyranoside; 3,4′,5,7-Tetrahydroxyflavone 3-glucoside
Appearance Solid
CAS # 480-10-4
Molecular Formula C₂₁H₂₀O₁₁
Molecular Weight 448.38
Purity 95%
Solubility ~30 mg/ml in DMSO and DMF
SMILES C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O
InChi InChI=1S/C21H20O11/c22-7-13-15(26)17(28)18(29)21(31-13)32-20-16(27)14-11(25)5-10(24)6-12(14)30-19(20)8-1-3-9(23)4-2-8/h1-6,13,15,17-18,21-26,28-29H,7H2/t13-,15-,17+,18-,21+/m1/s1
InChi Key JPUKWEQWGBDDQB-QSOFNFLRSA-N
PubChem CID 5282102
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Astragalin is a flavonoid isolated from leaves of persimmon, green tea seeds, wine and American pokeweed. It shows anti-inflammatory and anti-oxidant activity. It dose-dependently (20-80 µg/ml) inhibits IL-1β-stimulated nitric oxide and prostaglandin E2 (PGE2) production in patient-derived osteoarthritis chondrocytes. It also inhibits IL-1β-stimulated expression of nitric oxide synthase (NOS), COX-2 and activation of MAPK and NF-κB signaling. It (1-20 µM) dose-dependently prevents the loss of E-cadherin, expression of vimentin, and production of collagen type-1 in hydrogen peroxide-exposed human bronchial epithelial cells in vitro. It (10-20 mg/kg, p.o.) also reduces reactive oxygen species (ROS) production, collagen fiber deposition, and autophagosome formation in the epithelial lung tissue of ovalbumin-challenged mice.


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