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Astilbin

A flavonoid that displays diverse biological activities
Catalog #: B2616
SKU-Size Size Price Qty
B2616-5 5 mg
$75.00
B2616-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name (2R,3R)-3-[(6-deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one, Taxifolin 3-O-rhamnoside
Appearance White to off-white solid
CAS # 29838-67-3
Molecular Formula C₂₁H₂₂O₁₁
Molecular Weight 450.39
Purity ≥98%
Solubility ~10 mg/ml in DMSO
SMILES OC1=CC(O)=C(C([[email protected]](O[[email protected]@]2([H])[[email protected]](O)[[email protected]](O)[[email protected]@H](O)[[email protected]](C)O2)[[email protected]@H](C3=CC=C(O)C(O)=C3)O4)=O)C4=C1
InChi InChI=1S/C21H22O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-26,28-29H,1H3/t7-,15-,17+,18+,19+,20-,21-/m0/s1
InChi Key ZROGCCBNZBKLEL-MPRHSVQHSA-N
PubChem CID 119258
MDL Number MFCD20274680
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Astilbin is a flavonoid that displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities. It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive oxygen species (ROS) in HEK293 cells when used at a concentration of 200 μM. It increases renal glutathione (GSH) levels and superoxide dismutase (SOD) and catalase activity and reduces serum creatinine and blood urea nitrogen (BUN) levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity.


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