A potent dual inhibitor of SYK/JAK kinases
Catalog #: B3318 | abID:

Product Details

Alternate Name ASN002 1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile
Appearance Crystalline solid
CAS # 1425381-60-7
Molecular Formula C₂₄H₂₈N₈O₂
Molecular Weight 460.54
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
InChi InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29)
PubChem CID 71269142
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


ASN-002 (Gusacitinib) is a potent dual inhibitor of SYK/JAK kinases. ASN-002 displays strong antitumor activity in both hematological and solid tumor xenograft models. ASN-002 strongly suppresses the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively.

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