Product Details
| Cat # +Size | 3128-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | ASK1/MAPKKK5 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide corresponding to residue surrounding amino acid 1359 of human ASK1 |
| Accession # | Q99683 |
| Gene ID | 4217 |
| Appearance | Colorless liquid |
| Concentration | 0.2 mg/ml |
| Formulation | 100 µg (0.2 mg/ml) immunoaffinity purified, rabbit anti-ASK1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide. |
| Purification | Affinity purified |
| Species Reactivity | Human |
| Application | Western blot, Immunofluorescence |
| Application & Usage | Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects the 155 kDa ASK1 protein in human SW1353 cell lysate by immunoblotting. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
ASK1 (Apoptosis Signal-regulating Kinase 1) activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-Jun N-terminal Kinase (JNK) and p38 MAP Kinase. ASK1 is activated by TNFR and Fas throμgh the interaction with members of the TRAF Family and the Fas-associated protein Daxx. Overexpression of ASK1 induces apoptosis. However, a catalytically inactive form of ASK1 has been shown to inhibit TNF-α induced apoptosis.
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