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ASH2 polyclonal antibody

Polyclonal Antibody to detect Ash2 in mouse samples.
Catalog #: 6836

In stock

$245.00

Product Details

Cat # +Size 6836-50
Size 50 μl
Antibody Target ASH2
Alternate Name ASH2L, ASH2L1, ASH2L2, Bre2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Polyclonal antibody raised in rabbit against mouse Ash2 (absent, small, or homeotic 2), using 3 different KLH-conjugated synthetic peptides, 2 containing an amino acid sequence from the central and 1 containing an amino acid sequence from the C-terminal p
Accession # Q9UBL3
Gene ID 9070
Appearance Colorless liquid
Formulation In PBS with 0.05% (W/V) sodium azide.
Purification Whole Anti-Sera
Species Reactivity Mouse.
Application Western blot, ELISA.
Positive Control Western blot: mouse fibroblasts and neural stem cells, ELISA: Peptides, IF: NIH3T3 cells.
Application & Usage ELISA: 1:100 – 1:500, Western Blotting: 1:500 – 1:1000, IF: 1:200.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ash2 is a component of the Set1/Ash2 histone methyltransferase (HMT) complex. This complex specifically methylates K4 of histone H3, thereby activating transcription. Methylation of K4 is blocked by premethylation of the neighboring K9, a repressor of transcription. This indicates that the Set1/Ash2 HMT complex mediates the crosstalk between K9 methylation and K4 methylation. Ash2 plays a role in hematopoiesis and may be associated with some kinds of leukemia.


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