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An inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO)
Catalog #: B3223
SKU-Size Size Price Qty
B3223-250 250 μg
B3223-1000 1 mg
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Product Details

Alternate Name 5-chloro-3-[(2E,6E)-7-[(2S)-5,5-dimethyl-4-oxo-tetrahydrofuran-2-yl]-3-methyl-octa-2,6-dienyl]-2,4-dihydroxy-6-methyl-benzaldehyde
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 38462-04-3
Molecular Formula C₂₃H₂₉ClO₅
Molecular Weight 420.93
Purity ≥98%
Solubility DMSO
InChi InChI=1S/C23H29ClO5/c1-13(7-6-8-14(2)18-11-19(26)23(4,5)29-18)9-10-16-21(27)17(12-25)15(3)20(24)22(16)28/h8-9,12,18,27-28H,6-7,10-11H2,1-5H3/b13-9+,14-8+/t18-/m0/s1
PubChem CID 6434242
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ascofuranone, a compound isolated from the phytopathogenic fungus, Ascochyta visiae, acts as a potent inhibitor of trypanosome alternative oxidase (TAO). (TAO) is the terminal oxidase of the respiratory chain of long slender bloodstream forms of the African trypanosome, which causes sleeping sickness in human and nagana in cattle. Ascofuranone also suppresses EGF-induced HIF-1α protein translation through the inhibition of Akt/mTOR/p70S6 kinase signaling pathways and plays a novel role in the anti-angiogenic action.

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